Intensity of Intrathecal Total IgG Synthesis in Multiple Sclerosis Correlates with the Degree of Pleocytosis, Diversity of Intrathecal Antiviral Antibody Specificities, and Female Sex
Benjamin Vlad, Marc Hilty, Stephan Neidhart, Klara Asplund Högelin, Mario Ziegler, Mohsen Khademi, Andreas Lutterotti, Axel Regeniter, Roland Martin, Faiez Al Nimer, Ilijas Jelcic · 2024
Read Intensity of Intrathecal Total IgG Synthesis in Multiple Sclerosis Correlates with the Degree of Pleocytosis, Diversity of Intrathecal Antiviral Antibody Specificities, and Female Sex by Benjamin Vlad, Marc Hilty, Stephan Neidhart, Klara Asplund Högelin, Mario Ziegler, Mohsen Khademi, Andreas Lutterotti, Axel Regeniter, Roland Martin, Faiez Al Nimer, Ilijas Jelcic (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11672439.txt.
Description
Benjamin Vlad and ten colleagues analyzed spinal fluid from 390 people with multiple sclerosis, focusing on antibody production inside the nervous system. Making IgG antibodies within the spinal fluid is a hallmark of the disease. Most studies only record whether production occurs. The twenty twenty-four study instead measured its intensity using Reiber's formula. Patients were all untreated and had relapsing-remitting disease.
Stronger antibody production correlated with higher white cell counts in the fluid. It also tracked with broader antiviral antibody patterns, the MRZ reaction, against measles, rubella, and chickenpox viruses. Female sex was another correlate named in the title. These links help researchers understand what drives the immune activity that defines MS spinal fluid. Intensity, the authors argue, carries information that a simple yes-or-no result misses.
Catalog record
| CREATOR | Benjamin Vlad, Marc Hilty, Stephan Neidhart, Klara Asplund Högelin, Mario Ziegler, Mohsen Khademi, Andreas Lutterotti, Axel Regeniter, Roland Martin, Faiez Al Nimer, Ilijas Jelcic |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |