Engineering a Mesoporous Silicon Nanoparticle Cage to Enhance Performance of a Phosphotriesterase Enzyme for Degradation of VX Nerve Agent
Yi‐Sheng Lu, Eduardo Reynoso Moreno, Yubin Huang, Ruhan Fan, Ashley T. Tucker, Linnzi K. Wright, Ronald A. Evans, Brooke M. Ahern, Donald E. Owens, Stephen A. Chappell, Dale J. Christensen, John Dresios, Michael J. Sailor · 2024
Read Engineering a Mesoporous Silicon Nanoparticle Cage to Enhance Performance of a Phosphotriesterase Enzyme for Degradation of VX Nerve Agent by Yi‐Sheng Lu, Eduardo Reynoso Moreno, Yubin Huang, Ruhan Fan, Ashley T. Tucker, Linnzi K. Wright, Ronald A. Evans, Brooke M. Ahern, Donald E. Owens, Stephen A. Chappell, Dale J. Christensen, John Dresios, Michael J. Sailor (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11672247.txt.
Description
Yi-Sheng Lu and co-authors cage a useful enzyme inside tiny silicon particles to help it break down a nerve agent, in work published in 2024. The enzyme can split organophosphate compounds, a class that includes the agent VX. On its own, though, the enzyme is fragile and hard to recover after use.
Placed in the cage, the enzyme worked about twice as fast on a stand-in compound as the free enzyme did. The cage also shielded it from heat and from being cut up by other enzymes. The loaded particles kept working through seven cycles of use and recovery. In a gel on rabbit skin, and in tests with human blood, the construct stayed active against VX.
Catalog record
| CREATOR | Yi‐Sheng Lu, Eduardo Reynoso Moreno, Yubin Huang, Ruhan Fan, Ashley T. Tucker, Linnzi K. Wright, Ronald A. Evans, Brooke M. Ahern, Donald E. Owens, Stephen A. Chappell, Dale J. Christensen, John Dresios, Michael J. Sailor |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 68 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |