Identification of ANXA1 as a Novel Upstream Negative Regulator of Notch1 Function in AML (Adv. Sci. 48/2024)
Gang Shao, Xi Wang, Yiting Zheng, Junjie Ma, Lei Wang, Zhibin Yan, Zeyu Sun, Shuyuan Zhang, Hongzhang Wu, Yudie Lv, Hemiao Huang, Jianhu Li, Tianyi Zhu, Bing Yang, Nanxi Wang, Tao Chen, Xuancheng Guo, Yuanting Jin, Jian Kang, Huafeng Wang, Yihai Cao, Caiyun Fu · 2024
Read Identification of ANXA1 as a Novel Upstream Negative Regulator of Notch1 Function in AML (Adv. Sci. 48/2024) by Gang Shao, Xi Wang, Yiting Zheng, Junjie Ma, Lei Wang, Zhibin Yan, Zeyu Sun, Shuyuan Zhang, Hongzhang Wu, Yudie Lv, Hemiao Huang, Jianhu Li, Tianyi Zhu, Bing Yang, Nanxi Wang, Tao Chen, Xuancheng Guo, Yuanting Jin, Jian Kang, Huafeng Wang, Yihai Cao, Caiyun Fu (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11672243.txt.
Description
A journal cover feature from 2024 presents work by Gang Shao, Caiyun Fu, and co-authors on acute myeloid leukemia, a fast-growing blood cancer. The cover image shows a leukemia cell and explains, in picture form, how a protein called ANXA1 grips a second protein, Notch1, inside the cell. That grip leads to Notch1 being broken down.
The feature explains that short peptide blockers can compete for ANXA1 and free Notch1. Once freed, part of Notch1 is cut loose and can switch genes back on, restoring a tumor-blocking role in the cancer. Readers get the core idea of the study as told through its cover art.
Catalog record
| CREATOR | Gang Shao, Xi Wang, Yiting Zheng, Junjie Ma, Lei Wang, Zhibin Yan, Zeyu Sun, Shuyuan Zhang, Hongzhang Wu, Yudie Lv, Hemiao Huang, Jianhu Li, Tianyi Zhu, Bing Yang, Nanxi Wang, Tao Chen, Xuancheng Guo, Yuanting Jin, Jian Kang, Huafeng Wang, Yihai Cao, Caiyun Fu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 1004 bytes |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |