High-Affinity Lectin Ligands Enable the Detection of Pathogenic Pseudomonas aeruginosa Biofilms: Implications for Diagnostics and Therapy
Eva Zahorska, Lisa Marie Denig, Stefan Lienenklaus, Sakonwan Kuhaudomlarp, Thomas Tschernig, Peter Lipp, Antje Munder, Emilie Gillon, Saverio Minervini, Varvara Verkhova, Anne Imberty, Stefanie Wagner, Alexander Titz · 2024
Read High-Affinity Lectin Ligands Enable the Detection of Pathogenic Pseudomonas aeruginosa Biofilms: Implications for Diagnostics and Therapy by Eva Zahorska, Lisa Marie Denig, Stefan Lienenklaus, Sakonwan Kuhaudomlarp, Thomas Tschernig, Peter Lipp, Antje Munder, Emilie Gillon, Saverio Minervini, Varvara Verkhova, Anne Imberty, Stefanie Wagner, Alexander Titz (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11672137.txt.
Description
Eva Zahorska and co-authors build glowing probes that light up a dangerous bacterium's biofilms, in a 2024 study. The germ is a top-priority pathogen. Its chronic infections hide inside biofilms. Naming the germ today takes slow culturing or a biopsy. No fast, specific test exists. The probes target two sugar-binding proteins on the biofilm surface. They mimic the sugars those proteins grab.
Several probes were made and tested on lab biofilms. One design reached very tight binding, in the low nanomolar range. Tight binding is vital for use inside the body. The probe gathered in biofilms even under flowing fluid. Its glow color did not change that behavior. In infected mouse lungs, the probes gathered at the infection site. Imaging revealed them there. The authors propose such probes as fast diagnostics. Faster naming means faster, better-matched treatment. Therapy guided by the same targets is a further hope.
Catalog record
| CREATOR | Eva Zahorska, Lisa Marie Denig, Stefan Lienenklaus, Sakonwan Kuhaudomlarp, Thomas Tschernig, Peter Lipp, Antje Munder, Emilie Gillon, Saverio Minervini, Varvara Verkhova, Anne Imberty, Stefanie Wagner, Alexander Titz |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |