Are we making progress in curing advanced cervical cancer—again?
Jacob Christian Lindegaard, Primoz Petric, Li-Tee Tan, Peter Hoskin, Maximilian P Schmid, Ina Jürgenliemk-Schulz, Umesh Mahantshetty, Christian Kirisits, Richard Pötter, Linda Gough · 2024
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Description
A team of cancer specialists asks whether adding chemotherapy before main treatment truly helps women with advanced cervical cancer. A recent large trial found that six weekly rounds of two drugs before chemoradiation raised survival. Some doctors now call that sequence the new standard, and new trials are being built on it.
Writing as a team, the authors urge caution. The trial began before modern, image-guided radiation became common, so its standard arm did worse than today's best care achieves. Its patients were also younger and less ill than most. The team argues most women treated with modern radiation gain nothing from the added drugs and may be harmed, though a small group might benefit. Finding that group, they say, is the real task ahead.
Catalog record
| CREATOR | Jacob Christian Lindegaard, Primoz Petric, Li-Tee Tan, Peter Hoskin, Maximilian P Schmid, Ina Jürgenliemk-Schulz, Umesh Mahantshetty, Christian Kirisits, Richard Pötter, Linda Gough |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |