Cellular immunotherapies and immune cell depleting therapies in inflammatory bowel diseases: the next magic bullet?
Markus Friedrich Neurath, Bruce Eric Sands, Florian Rieder · 2024
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Description
Markus Friedrich Neurath, Bruce Eric Sands, and Florian Rieder reviewed a new class of treatments for inflammatory bowel diseases: therapies built from living immune cells or designed to remove harmful ones. Despite modern biologics and small-molecule drugs, many patients still cannot control gut inflammation. The review covers engineered CAR-T cells, two kinds of calming regulatory T cells, and antibodies such as rosnilimab that deplete selected immune cells.
These approaches aim to hit several disease pathways at once and to switch on the body's own inflammation-resolving routes, offering a chance at lasting remission. Cell therapies could reset a misdirected immune system rather than merely suppress it. The authors weigh early evidence and safety questions, asking whether this strategy could become the field's next major advance.
Catalog record
| CREATOR | Markus Friedrich Neurath, Bruce Eric Sands, Florian Rieder |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |