Lynch syndrome diagnostic testing pathways in endometrial cancers: a nationwide English registry-based study
Lucy Loong, Catherine Huntley, Joanna Pethick, Fiona McRonald, Francesco Santaniello, Brian Shand, Oliver Tulloch, Shilpi Goel, Margreet Lüchtenborg, Sophie Allen, Bethany Torr, Katie Snape, Angela George, Fiona Lalloo, Gail Norbury, Diana M Eccles, Marc Tischkowitz, Antonis C Antoniou, Paul Pharoah · 2024
Read Lynch syndrome diagnostic testing pathways in endometrial cancers: a nationwide English registry-based study by Lucy Loong, Catherine Huntley, Joanna Pethick, Fiona McRonald, Francesco Santaniello, Brian Shand, Oliver Tulloch, Shilpi Goel, Margreet Lüchtenborg, Sophie Allen, Bethany Torr, Katie Snape, Angela George, Fiona Lalloo, Gail Norbury, Diana M Eccles, Marc Tischkowitz, Antonis C Antoniou, Paul Pharoah (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11671912.txt.
Description
Lucy Loong and co-authors audit how Lynch syndrome testing ran for womb cancers across England in 2019, in a 2024 paper. For women with the inherited syndrome, womb cancer is often the first cancer to show. A triage path of tumor tests then gene tests can catch the small share of cases it causes.
Registry data covered near eight thousand diagnoses. Under a fifth had a tumor test logged, with shares swinging by region and age. Of those whose tumor tests flagged them, only a quarter got the gene test. The median wait from diagnosis to gene test ran near ten months. The authors frame the gaps as a base line for new universal testing rules.
Catalog record
| CREATOR | Lucy Loong, Catherine Huntley, Joanna Pethick, Fiona McRonald, Francesco Santaniello, Brian Shand, Oliver Tulloch, Shilpi Goel, Margreet Lüchtenborg, Sophie Allen, Bethany Torr, Katie Snape, Angela George, Fiona Lalloo, Gail Norbury, Diana M Eccles, Marc Tischkowitz, Antonis C Antoniou, Paul Pharoah |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |