ATP5J regulates microglial activation via mitochondrial dysfunction, exacerbating neuroinflammation in intracerebral hemorrhage
Naixin Ren, Hutao Zhang, Tao Li, Huafang Ji, Zhen Zhang, He Wu · 2024
Read ATP5J regulates microglial activation via mitochondrial dysfunction, exacerbating neuroinflammation in intracerebral hemorrhage by Naixin Ren, Hutao Zhang, Tao Li, Huafang Ji, Zhen Zhang, He Wu (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11671693.txt.
Description
Ren and co-authors study a mitochondrial protein that may worsen brain bleed harm. Bleeding in the brain triggers swelling and cell death near the clot. Microglia, the brain immune cells, drive much of that harm. The protein ATP5J rose in microglia after a bleed in mice. Raising ATP5J made brain scores, barrier leaks, and water content worse.
Lowering ATP5J had the reverse effect and eased the damage. High ATP5J also fired up microglia and raised cell death nearby. In cell tests, ATP5J pushed microglia toward a harmful state. Blocking ATP5J calmed excess mitochondrial splitting and cut reactive oxygen output. The work names ATP5J as a possible drug target after brain bleeds.
Catalog record
| CREATOR | Naixin Ren, Hutao Zhang, Tao Li, Huafang Ji, Zhen Zhang, He Wu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |