Propofol Suppresses Ferroptosis via Modulating eNOS/NO Signaling Pathway to Improve Traumatic Brain Injury
Zi‐Lei Zheng, Xu‐Peng Wang, Yu‐Fei Hu, Wen‐Guang Li, Qi Zhou, Fang Xu, Qiu‐Jun Wang · 2024
Read Propofol Suppresses Ferroptosis via Modulating eNOS/NO Signaling Pathway to Improve Traumatic Brain Injury by Zi‐Lei Zheng, Xu‐Peng Wang, Yu‐Fei Hu, Wen‐Guang Li, Qi Zhou, Fang Xu, Qiu‐Jun Wang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11671348.txt.
Description
Zheng and six co-authors study the anesthetic propofol as a treatment for traumatic brain injury in mice in a 2024 paper. Gene data first showed early changes tied to iron handling, cell death, and inflammation after injury. Ferroptosis, an iron-driven form of cell death, was a focus.
Injured mice given propofol showed less iron buildup and less ferroptosis in the brain. Neuron health improved and cell death fell. Long-term inflammation markers also eased, and memory tests improved. The benefit ran through a nitric oxide pathway, since blocking its key enzyme reversed the gains. The authors offer a scientific basis for propofol as a brain-protective drug.
Catalog record
| CREATOR | Zi‐Lei Zheng, Xu‐Peng Wang, Yu‐Fei Hu, Wen‐Guang Li, Qi Zhou, Fang Xu, Qiu‐Jun Wang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |