Pilot study characterizing a single pooled preparation of equine platelet lysate for nebulization in the horse
Patricia Egli, Lindsey Boone, Laura Huber, Courtney Higgins, Pankaj P. Gaonkar, Justine Arrington, Maria C. Naskou, John Peroni, Julie Gordon, Kara M. Lascola · 2024
Read Pilot study characterizing a single pooled preparation of equine platelet lysate for nebulization in the horse by Patricia Egli, Lindsey Boone, Laura Huber, Courtney Higgins, Pankaj P. Gaonkar, Justine Arrington, Maria C. Naskou, John Peroni, Julie Gordon, Kara M. Lascola (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11670369.txt.
Description
Patricia Egli and co-authors run a pilot study on whether equine platelet lysate can be given to horses as an inhaled mist. The lysate, made from blood platelets, kills bacteria and calms inflammation, which suits it for treating bacterial pneumonia in horses. No one knew whether a horse nebulizer would leave it intact. Their 2024 study pools a single batch of lysate and passes it through a nebulizer designed for horses.
The mist flowed at 0.8 milliliters per minute, with a median particle size near five micrometers. About 52 percent of the particles were small enough to travel deep into the lung. The protein makeup shifted during nebulization, yet the antibacterial effect held for two of three test bacteria. One bacterium grew slightly more after nebulization. The team calls the route sound in the laboratory and supports trials in live horses.
Catalog record
| CREATOR | Patricia Egli, Lindsey Boone, Laura Huber, Courtney Higgins, Pankaj P. Gaonkar, Justine Arrington, Maria C. Naskou, John Peroni, Julie Gordon, Kara M. Lascola |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |