Internal feedback circuits among MEX-5, MEX-6, and PLK-1 maintain faithful patterning in the Caenorhabditis elegans embryo
Alexandre Pierre Vaudano, Françoise Schwager, Monica Gotta, Sofia Barbieri · 2024
Read Internal feedback circuits among MEX-5, MEX-6, and PLK-1 maintain faithful patterning in the Caenorhabditis elegans embryo by Alexandre Pierre Vaudano, Françoise Schwager, Monica Gotta, Sofia Barbieri (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11670235.txt.
Description
Alexandre Pierre Vaudano, Françoise Schwager, Monica Gotta, and Sofia Barbieri map the feedback loops that pattern a worm embryo's first cell. In Caenorhabditis elegans, two RNA-binding proteins, MEX-5 and MEX-6, gather at the front of the cell. They help place other factors, including the kinase PLK-1, and support the cell's front-back polarity.
Though the two MEX proteins are close cousins, the team found their gradients are tuned in different ways. PLK-1 lifts MEX-5 only indirectly, by steadying the cell cortex. It shapes MEX-6 by touching the protein directly. The picture that emerges is a circuit: the kinase ties the MEX proteins to the cortex so polarity is set up faithfully and held in place.
Catalog record
| CREATOR | Alexandre Pierre Vaudano, Françoise Schwager, Monica Gotta, Sofia Barbieri |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |