Corticosteroids reduce pathological angiogenesis yet compromise reparative vascular remodeling in a model of retinopathy
Masayuki Hata, Maki Hata, Agnieszka Dejda, Frédérique Pilon, Roberto Diaz-Marin, Frédérik Fournier, Jean-Sebastien Joyal, Gael Cagnone, Yotaro Ochi, Sergio Crespo-Garcia, Ariel M. Wilson, Przemyslaw Sapieha · 2024
Read Corticosteroids reduce pathological angiogenesis yet compromise reparative vascular remodeling in a model of retinopathy by Masayuki Hata, Maki Hata, Agnieszka Dejda, Frédérique Pilon, Roberto Diaz-Marin, Frédérik Fournier, Jean-Sebastien Joyal, Gael Cagnone, Yotaro Ochi, Sergio Crespo-Garcia, Ariel M. Wilson, Przemyslaw Sapieha (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11670060.txt.
Description
Masayuki Hata and co-authors study steroid treatment in an eye disease model, in a research paper from 2024. In retinopathy, harmful new blood vessels grow in the retina, while repair of damaged vessels is also needed. Steroids calm swelling, but swelling also helps guide repair, so timing may matter.
In mice raised with excess oxygen, the steroid drug cut harmful vessel growth early on. Later, the same drug slowed repair by weakening key immune cell groups. Tests that removed parts of the immune response showed split roles for those cells. The paper warns that broad calming drugs can help and harm in the same disease.
Catalog record
| CREATOR | Masayuki Hata, Maki Hata, Agnieszka Dejda, Frédérique Pilon, Roberto Diaz-Marin, Frédérik Fournier, Jean-Sebastien Joyal, Gael Cagnone, Yotaro Ochi, Sergio Crespo-Garcia, Ariel M. Wilson, Przemyslaw Sapieha |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |