Redox-Responsive Polymeric Nanogels as Efficient mRNA Delivery Vehicles in Caenorhabditis elegans
Rupali Dabas, Alan Koh, David Carling, Nazila Kamaly, André E. X. Brown · 2024
Read Redox-Responsive Polymeric Nanogels as Efficient mRNA Delivery Vehicles in Caenorhabditis elegans by Rupali Dabas, Alan Koh, David Carling, Nazila Kamaly, André E. X. Brown (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11669991.txt.
Description
Rupali Dabas and co-authors test tiny gel carriers for delivering mRNA in worms in a 2024 study. Getting fragile RNA into the roundworm Caenorhabditis elegans is hard, and standard gene methods are slow and labor-heavy. Their carriers are polymer nanogels that respond to the chemical state inside cells, releasing cargo where a reducing agent is rich.
The gels packed up to about 72 percent of the RNA offered and released most of it within a day at cell-like levels of the agent. As a proof of concept, the team delivered mRNA for a glowing green protein, and the protein appeared in the worm's gut after one day, a first for this method. The work opens a simpler route for RNA studies in worms.
Catalog record
| CREATOR | Rupali Dabas, Alan Koh, David Carling, Nazila Kamaly, André E. X. Brown |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 16 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |