The Effect of Inhaled Beta-2 Agonists on Heart Rate in Patients With Asthma: Sensor-Based Observational Study
Rishi Jayant Khusial, Jacob K Sont, Omar S Usmani, Matteo Bonini, Kian Fan Chung, Stephen James Fowler, Persijn J Honkoop, John Rivers, John Blakey, Luis J Nannini · 2024
Read The Effect of Inhaled Beta-2 Agonists on Heart Rate in Patients With Asthma: Sensor-Based Observational Study by Rishi Jayant Khusial, Jacob K Sont, Omar S Usmani, Matteo Bonini, Kian Fan Chung, Stephen James Fowler, Persijn J Honkoop, John Rivers, John Blakey, Luis J Nannini (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11669870.txt.
Description
The authors check whether inhaled asthma drugs raise heart rate, using wearable sensors rather than clinic visits. The drugs open airways by stimulating beta-2 receptors, but the same receptors sit in heart cells, so a spillover effect is plausible. Data came from an observational study of adults with uncontrolled asthma. Smart inhalers logged each dose, questionnaires backed them up, and a wrist tracker recorded heart rate around the clock.
Long-acting inhalers made almost no difference: users averaged just 0.8 beats per minute higher across the day. Short-acting rescue inhalers told another story. Right after a puff, heart rate jumped steeply, and it took 138 minutes to settle back to normal. The authors conclude the daily drugs are gentle on the heart, while rescue puffs carry a clear short-lived spike.
Catalog record
| CREATOR | Rishi Jayant Khusial, Jacob K Sont, Omar S Usmani, Matteo Bonini, Kian Fan Chung, Stephen James Fowler, Persijn J Honkoop, John Rivers, John Blakey, Luis J Nannini |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |