Regulation of bile acids and their receptor FXR in metabolic diseases
Yao Li, Lulu Wang, Qing Yi, Linsong Luo, Yuxia Xiong · 2024
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Description
Yao Li and four co-authors review how bile acids and their receptor FXR steer metabolic disease. Their review appeared in twenty twenty-four. Bile acids do double duty: they help digest fat and act as hormone-like signals across the body.
When their mix goes wrong, the FXR receptor misfires in liver and gut, feeding obesity, fatty liver, and diabetes. Switching FXR on can trim fat production and curb glucose output. The gut's FXR also talks to the liver's copy, an organ-to-organ line that suggests new drug angles. The authors gather the mechanism and the therapeutic attempts built on it. Their map is meant to guide treatment ideas for the metabolic epidemic.
Catalog record
| CREATOR | Yao Li, Lulu Wang, Qing Yi, Linsong Luo, Yuxia Xiong |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |