Ferrostatin-1 improves acute sepsis-induced cardiomyopathy via inhibiting neutrophil infiltration through impaired chemokine axis
Jialin Li, Fang Xiao, Bingsen Lin, Zhilei Huang, Mingyue Wu, Huan Ma, Ruoxu Dou, Xiaodong Song, Zhongxing Wang, Changjie Cai, Xiangdong Guan, Jie Xu, Fu-Li Xiang · 2024
Read Ferrostatin-1 improves acute sepsis-induced cardiomyopathy via inhibiting neutrophil infiltration through impaired chemokine axis by Jialin Li, Fang Xiao, Bingsen Lin, Zhilei Huang, Mingyue Wu, Huan Ma, Ruoxu Dou, Xiaodong Song, Zhongxing Wang, Changjie Cai, Xiangdong Guan, Jie Xu, Fu-Li Xiang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11669711.txt.
Description
Li and co-authors test whether ferrostatin-1 protects the heart during early sepsis in mice. Sepsis often weakens the heart and raises death risk, with no good tests or care yet. Ferroptosis, an iron-driven cell death, is thought to play a key role.
Mice got sepsis through a gut puncture model, with some pretreated with the drug. At six hours, standard pump scores still looked normal after surgery. Strain analysis, a finer measure, showed clear loss of contraction. The drug curbed white cell entry into heart tissue by weakening a chemokine signal path. Survival was tracked for forty-eight hours.
Catalog record
| CREATOR | Jialin Li, Fang Xiao, Bingsen Lin, Zhilei Huang, Mingyue Wu, Huan Ma, Ruoxu Dou, Xiaodong Song, Zhongxing Wang, Changjie Cai, Xiangdong Guan, Jie Xu, Fu-Li Xiang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |