Interpreting high levels of unfolded Von Willebrand Factor in patients with the antiphospholipid syndrome
Romy de Laat-Kremers, Shengshi Huang, Hugo ten Cate, Marisa Ninivaggi, Bas de Laat, Katrien Devreese · 2024
Read Interpreting high levels of unfolded Von Willebrand Factor in patients with the antiphospholipid syndrome by Romy de Laat-Kremers, Shengshi Huang, Hugo ten Cate, Marisa Ninivaggi, Bas de Laat, Katrien Devreese (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11669600.txt.
Description
Romy de Laat-Kremers and co-authors read high levels of unfolded von Willebrand factor in people with antiphospholipid syndrome. This syndrome causes clots, driven by antibodies against a blood protein that normally tempers platelet binding. When von Willebrand factor unfolds, it grabs platelets without needing collagen. Their 2024 study compares four groups: syndrome patients, other clot patients, other autoimmune patients, and healthy controls.
Unfolded factor ran higher in all three patient groups than in controls, with the syndrome group near the top. Levels past a high cutoff were far more common in the syndrome group than chance allows. The authors weigh what the marker adds beyond standard antibody tests. Hematologists get a candidate signal for a clotting disorder that hides well.
Catalog record
| CREATOR | Romy de Laat-Kremers, Shengshi Huang, Hugo ten Cate, Marisa Ninivaggi, Bas de Laat, Katrien Devreese |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |