The JNK Signaling Pathway Regulates Seizures Through ENT1 in Pilocarpine‐Induced Epilepsy Rat Model
Shun Liu, Zhong Luo, Fangjing Li, Lijia Zhang, Mingxiang Xie, Juan Yang, Zucai Xu · 2024
Read The JNK Signaling Pathway Regulates Seizures Through ENT1 in Pilocarpine‐Induced Epilepsy Rat Model by Shun Liu, Zhong Luo, Fangjing Li, Lijia Zhang, Mingxiang Xie, Juan Yang, Zucai Xu (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11669570.txt.
Description
Shun Liu and six co-authors published a 2024 rat study on a signaling pathway that may drive seizures through a transporter protein. The pathway, named JNK, is a stress response chain inside cells. The transporter, ENT1, moves adenosine, a calming chemical, across cell membranes. If JNK raises ENT1, extracellular adenosine and glutamate could shift and seizures could worsen.
Epilepsy was induced in adult rats with a standard drug, and some received a JNK blocker. Blotting and staining tracked ENT1 and JNK activity in the hippocampus, the brain region central to this epilepsy type. Fine sampling measured adenosine and glutamate outside cells. Blocking JNK lowered ENT1 expression and reduced seizure intensity in the rats. The pathway is a candidate target for new epilepsy drugs.
Catalog record
| CREATOR | Shun Liu, Zhong Luo, Fangjing Li, Lijia Zhang, Mingxiang Xie, Juan Yang, Zucai Xu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |