SUMO2 rescues neuronal and glial cells from the toxicity of P301L Tau mutant
Franca Orsini, Rosaria Pascente, Annacarla Martucci, Sara Palacino, Paul Fraser, Ottavio Arancio, Luana Fioriti · 2024
Read SUMO2 rescues neuronal and glial cells from the toxicity of P301L Tau mutant by Franca Orsini, Rosaria Pascente, Annacarla Martucci, Sara Palacino, Paul Fraser, Ottavio Arancio, Luana Fioriti (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11669524.txt.
Description
Franca Orsini and co-authors test, in a 2024 mouse study, whether boosting a protein-tagging system can shield brain cells from a toxic mutant tau protein. Tau clumps mark Alzheimer's and related dementias, and the tagging system runs low in patient brains. The team used viruses to add the mutant tau, with or without extra tagging protein, in the mouse memory center.
Mutant tau placed only in neurons still hurt nearby support cells too. Extra tagging protein fought the toxicity in both cell kinds. Stains and counts showed rescued cells and calmer support cell shapes. The authors suggest raising this tag is a candidate strategy against tau diseases, pending more work.
Catalog record
| CREATOR | Franca Orsini, Rosaria Pascente, Annacarla Martucci, Sara Palacino, Paul Fraser, Ottavio Arancio, Luana Fioriti |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |