Tomatidine relieves neuronal damage in spinal cord injury by inhibiting the inflammatory responses and apoptosis through blocking the NF-κB/CXCL10 pathway activation
Xu Wang, Wei Huang, Hao Sun, Hua Wang, Dongxu Wang, Yongxiang Wang · 2024
Read Tomatidine relieves neuronal damage in spinal cord injury by inhibiting the inflammatory responses and apoptosis through blocking the NF-κB/CXCL10 pathway activation by Xu Wang, Wei Huang, Hao Sun, Hua Wang, Dongxu Wang, Yongxiang Wang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11669516.txt.
Description
Xu Wang and five co-authors test a tomato compound on spinal cord injury in rats in a 2024 study. Crushed cords ignite inflammation and order damaged nerve cells to die, deepening paralysis. Tomatidine, a steroid-like molecule from tomato plants, had shown protective hints in the brain.
Injured rats dosed for a week moved better and kept drier, healthier cords, with less cell death under the microscope. Inflammatory messengers fell. In dish-grown nerve cells stressed with a bacterial toxin, the same shielding appeared. Both effects traced to one signaling chain the compound blocks; forcing that chain back on erased the benefit. The work names a candidate pathway for future cord therapies.
Catalog record
| CREATOR | Xu Wang, Wei Huang, Hao Sun, Hua Wang, Dongxu Wang, Yongxiang Wang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |