Soluble Urokinase Plasminogen Activator Receptor: A Useful Marker for Predicting Mortality in COVID-19 Patients
Tushar Sehgal, Ambika Anand, Gowtham Vijayabupathy, Maroof Khan · 2024
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Description
Tushar Sehgal and three co-authors test a blood marker for predicting death in COVID-19 patients in this 2024 paper. The marker, suPAR, reflects immune activation and had shown promise for forecasting respiratory failure. Their hospital study in New Delhi enrolled twenty-one confirmed patients and nine febrile controls. Blood was drawn on days one, five, and ten. Eight of the twenty-one patients died within the follow up window; no controls died. Marker levels ran far higher in patients than controls at every check.
Patients who died carried higher levels than survivors on all three days. A cutoff near 3.64 predicted death with eighty-eight percent sensitivity and about seventy-three percent specificity. The authors present suPAR as a practical triage aid: a single early value flags who needs the closest watch. They note the sample is small, ninety samples from thirty people.
Catalog record
| CREATOR | Tushar Sehgal, Ambika Anand, Gowtham Vijayabupathy, Maroof Khan |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |