Effect of Translation-Enhancing Nascent SKIK Peptide on the Arrest Peptides Containing Consecutive Proline
Yuma Nishikawa, Riko Fujikawa, Hideo Nakano, Takashi Kanamori, Teruyo Ojima-Kato · 2024
Read Effect of Translation-Enhancing Nascent SKIK Peptide on the Arrest Peptides Containing Consecutive Proline by Yuma Nishikawa, Riko Fujikawa, Hideo Nakano, Takashi Kanamori, Teruyo Ojima-Kato (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11669330.txt.
Description
Yuma Nishikawa and co-authors free stalled ribosomes with a four letter peptide tag in a 2024 study. Some peptide chains jam the ribosome mid build, above all runs of proline, which cuts protein yield. The SKIK tag is known to speed translation starts.
Placed near a jam sequence, SKIK eased the stall in both cell free and live cell runs, and its gap to the jam set the gain. With elongation factor P, the tag worked in concert to lift yields of proline rich proteins. Ribosome turnover by one jam chain sped more than tenfold. The trick aids protein making.
Catalog record
| CREATOR | Yuma Nishikawa, Riko Fujikawa, Hideo Nakano, Takashi Kanamori, Teruyo Ojima-Kato |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |