Time‐of‐day control of mitochondria regulates NLRP3 inflammasome activation in macrophages
James R O'Siorain, Shannon L Cox, Cloé Payet, Frances K Nally, Yan He, Tabea T Drewinksi, Oran D Kennedy, Jennifer K Dowling, Mark Mellett, James O Early, Annie M Curtis · 2024
Read Time‐of‐day control of mitochondria regulates NLRP3 inflammasome activation in macrophages by James R O'Siorain, Shannon L Cox, Cloé Payet, Frances K Nally, Yan He, Tabea T Drewinksi, Oran D Kennedy, Jennifer K Dowling, Mark Mellett, James O Early, Annie M Curtis (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11669068.txt.
Description
James O'Siorain and co-authors show that the body's daily clock tunes an inflammatory alarm in immune cells through their mitochondria. Macrophages, the immune cells studied, release inflammatory signals by assembling a complex called the NLRP3 inflammasome. Its activity rises and falls across the day, and the cell's power stations were suspected to set the rhythm.
Cells taken from mice at one time of day fired the alarm much more strongly than cells taken twelve hours earlier, and their mitochondria held a higher charge at the active time. Mice lacking the clock gene Bmal1 in their immune cells lost the quiet phase and over-fired the alarm. Collapsing the mitochondrial charge with a drug erased the time-of-day differences in all groups. The authors conclude that the clock gene steers the alarm by governing mitochondrial state.
Catalog record
| CREATOR | James R O'Siorain, Shannon L Cox, Cloé Payet, Frances K Nally, Yan He, Tabea T Drewinksi, Oran D Kennedy, Jennifer K Dowling, Mark Mellett, James O Early, Annie M Curtis |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |