Weizmannia coagulans BC99 alleviates hyperuricemia and oxidative stress via DAF-16/SKN-1 activation in Caenorhabditis elegan
Yinyin Gao, Cheng Li, Junfei Li, Mengyao Duan, Xuan Li, Lina Zhao, Ying Wu, Shaobin Gu · 2024
Read Weizmannia coagulans BC99 alleviates hyperuricemia and oxidative stress via DAF-16/SKN-1 activation in Caenorhabditis elegan by Yinyin Gao, Cheng Li, Junfei Li, Mengyao Duan, Xuan Li, Lina Zhao, Ying Wu, Shaobin Gu (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11668962.txt.
Description
Gao and co-authors test a probiotic bacterium against high uric acid in tiny worms, in a 2024 study. Excess uric acid in blood raises the risk of gout and kidney disease. The team fed the probiotic Weizmannia coagulans BC99 to Caenorhabditis elegans worms bred as a model of the condition. Two doses were tried, and chemical profiling tracked the worms' internal metabolites.
The probiotic lowered uric acid and the enzyme that makes it, and the worms lived longer and moved better. It switched on two master stress regulators, which raised antioxidant defenses and cut harmful reactive oxygen. Chemical profiling showed shifts in amino acid and fat pathways. The higher dose worked best. Results in worms are early evidence, but they map a plausible route to relief.
Catalog record
| CREATOR | Yinyin Gao, Cheng Li, Junfei Li, Mengyao Duan, Xuan Li, Lina Zhao, Ying Wu, Shaobin Gu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |