Porcine peritoneal macrophages are susceptible to porcine reproductive and respiratory syndrome virus infection
Kassandra Durazo-Martinez, Jayeshbhai Chaudhari, Sushmita Kumari, Hiep L. X. Vu · 2024
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Description
Pig lung macrophages are the known doorway for a costly swine virus, but belly macrophages were long thought safe from it. Kassandra Durazo-Martinez and co-authors test that belief in this 2024 study of porcine reproductive and respiratory syndrome virus. Belly macrophages carried the virus's two entry receptors, just at lower levels than lung cells.
Despite the lower levels, both major virus types infected the belly cells. Letting the cells mature one day in culture raised infection tenfold. Blocking the main receptor with an antibody cut infection sharply, proving the same door is used. The finding widens the map of where this virus can live in a pig. That matters for control, since hidden reservoirs help outbreaks persist.
Catalog record
| CREATOR | Kassandra Durazo-Martinez, Jayeshbhai Chaudhari, Sushmita Kumari, Hiep L. X. Vu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |