Adding a twist to the loops: the role of DNA superhelicity in the organization of chromosomes by SMC protein complexes
Antonio Valdés, Christian H. Haering · 2024
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Description
Antonio Valdés and Christian Haering review how chromosome-organizing machines twist DNA in this two thousand twenty-four paper. SMC protein complexes, cohesin, condensin, and Smc5/6, shape chromosomes for segregation, gene control, and repair. Despite different jobs, they share two abilities: extruding DNA into large loops, and changing the DNA double helix's superhelicity, its twist and writhe. The review explores how these complexes influence DNA topology and debates what the twisting is for.
Loop extrusion alone does not fully explain chromosome structure, and topology changes may help organize, compact, or untangle chromosomes. New structural insights into the complexes' form suggest ways they grip and rotate DNA. The authors weigh evidence for the bodily roles of supercoiling by SMC complexes. The piece speaks to cell biologists refining models of how genomes fold in three dimensions.
Catalog record
| CREATOR | Antonio Valdés, Christian H. Haering |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |