Aptamer and N-Degron Ensemble (AptaGron) as a Target Protein Degradation Strategy
Mohammad · 2024
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Description
Al Mazid and co-authors presented a protein removal system in 2024 built from aptamers, though the catalog creator field gives only a first name. Targeted protein degradation is a promising drug strategy, but finding a specific binder for each target is hard. Aptamers, found by systematic screening, offer an alternative to small molecules.
Their design, AptaGron, pairs an aptamer with a peptide tag that marks proteins for destruction, joined through a nucleic acid linker instead of chemical conjugation. The system removed three target proteins that lack good small-molecule binders: tau, nucleolin, and a translation factor. The authors present AptaGron as a robust platform for degrading hard-to-drug proteins.
Catalog record
| CREATOR | Mohammad |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |