Medial pulvinar stimulation for focal drug-resistant epilepsy: interim 12-month results of the PULSE study
Francesca Pizzo, Romain Carron, Virginie Laguitton, Audrey Clement, Bernard Giusiano, Fabrice Bartolomei · 2024
Read Medial pulvinar stimulation for focal drug-resistant epilepsy: interim 12-month results of the PULSE study by Francesca Pizzo, Romain Carron, Virginie Laguitton, Audrey Clement, Bernard Giusiano, Fabrice Bartolomei (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11667892.txt.
Description
Francesca Pizzo and five co-authors present a 2024 interim report on brain stimulation for epilepsy that resists drugs and earlier stimulation. The PULSE study implants electrodes in the medial pulvinar, a thalamus relay, in patients with focal epilepsy who cannot have resective surgery. Twelve patients were planned; this report covers the first six at one year, with seizures, thinking, mood, and quality of life tracked every three months.
Five patients finished the year; one died early. Average seizure frequency fell about forty-five percent by one year, with two of five responding strongly. Seizure severity and quality of life improved significantly, and mood trended better. Thinking stayed stable or improved in three patients. Serious harms occurred: one brain bleed, one infection forcing removal, and one possible sudden death in epilepsy. The authors call the signal promising but demand larger studies.
Catalog record
| CREATOR | Francesca Pizzo, Romain Carron, Virginie Laguitton, Audrey Clement, Bernard Giusiano, Fabrice Bartolomei |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |