Kinetic Analysis of Cyclization by the Substrate-Tolerant Lanthipeptide Synthetase ProcM
Emily · 2024
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Description
Some bacteria build ring-shaped peptides using a famously flexible enzyme, ProcM, which handles about thirty different starting peptides with high accuracy. A research team measured the step-by-step rates of ring formation for one starter peptide and its variants in a 2024 study, to learn what decides the final ring pattern. Past work hinted the pattern is written in the peptide's own sequence rather than dictated by the enzyme.
Changing the sequence changed how fast each ring formed, and sometimes flipped the order of steps, producing different patterns. The results strongly back the sequence-rules view, which matters for using this enzyme to build libraries of new ringed peptides.
Catalog record
| CREATOR | Emily |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |