Endoplasmic reticulum stress-mediated apoptosis and autophagy in osteoarthritis: From molecular mechanisms to therapeutic applications
Yifan Lu, Jing Zhou, Hong Wang, Hua Gao, Eryu Ning, Zhiqiang Shao, Yuefeng Hao, Xing Yang · 2024
Read Endoplasmic reticulum stress-mediated apoptosis and autophagy in osteoarthritis: From molecular mechanisms to therapeutic applications by Yifan Lu, Jing Zhou, Hong Wang, Hua Gao, Eryu Ning, Zhiqiang Shao, Yuefeng Hao, Xing Yang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11667160.txt.
Description
Yifan Lu and seven co-authors review how endoplasmic reticulum stress drives cell death and self-digestion in osteoarthritis. The disease wears down articular cartilage, and chondrocytes are the only cells inside that tissue. Stressors such as low oxygen, poor nutrient supply, and collagen mutations leave misfolded proteins piled up in the endoplasmic reticulum. Cells respond with repair programs meant to restore balance.
When the stress is long or severe, those programs fail and apoptosis and autophagy fall out of control. That damage to chondrocytes pushes the disease forward. The review maps the molecular links and points to targets that could lead to new ways to prevent or treat osteoarthritis.
Catalog record
| CREATOR | Yifan Lu, Jing Zhou, Hong Wang, Hua Gao, Eryu Ning, Zhiqiang Shao, Yuefeng Hao, Xing Yang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 92 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |