Spns1-dependent endocardial lysosomal function drives valve morphogenesis through Notch1-signaling
Myra N. Chávez, Prateek Arora, Marco Meer, Ines J. Marques, Alexander Ernst, Rodrigo A. Morales Castro, Nadia Mercader · 2024
Read Spns1-dependent endocardial lysosomal function drives valve morphogenesis through Notch1-signaling by Myra N. Chávez, Prateek Arora, Marco Meer, Ines J. Marques, Alexander Ernst, Rodrigo A. Morales Castro, Nadia Mercader (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11667069.txt.
Description
Myra Chávez and co-authors ask how the heart builds its valves, using young zebrafish whose hearts can be watched while they live. Cells have a waste-clearing system built around small sacs called lysosomes, and its role in heart growth was not clear. The team tracked those sacs in the larval heart over time.
The sacs piled up near the zones where valves form. Fish with a faulty copy of a gene for the system had messy heart lining, poor valves, and blood flowing the wrong way. Adding back that gene, or a related signal gene, in the heart lining alone fixed much of the fault, which points to a local role.
Catalog record
| CREATOR | Myra N. Chávez, Prateek Arora, Marco Meer, Ines J. Marques, Alexander Ernst, Rodrigo A. Morales Castro, Nadia Mercader |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 113 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |