Diversity and evolution of tyrosinase enzymes involved in the adhesive systems of mussels and tubeworms
Emilie Duthoo, Jérôme Delroisse, Barbara Maldonado, Fabien Sinot, Cyril Mascolo, Ruddy Wattiez, Pascal Jean Lopez, Cécile Van de Weerdt, Matthew J. Harrington, Patrick Flammang · 2024
Read Diversity and evolution of tyrosinase enzymes involved in the adhesive systems of mussels and tubeworms by Emilie Duthoo, Jérôme Delroisse, Barbara Maldonado, Fabien Sinot, Cyril Mascolo, Ruddy Wattiez, Pascal Jean Lopez, Cécile Van de Weerdt, Matthew J. Harrington, Patrick Flammang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11667028.txt.
Description
Emilie Duthoo and co-authors catalog the enzymes behind the underwater glue of mussels and tubeworms. Both animals stick fast in the surf with proteins rich in DOPA, a modified building block that tyrosinase enzymes create from tyrosine and can push further. The team compiled the tyrosinases likely at work in the mussel Mytilus edulis and the tubeworm Sabellaria alveolata, and checked which ones switch on in the glue glands.
Some enzymes were indeed active in the glands, sharply so in mussels and more loosely in tubeworms. The sheer variety of forms hints that different enzymes handle different steps and targets. Family tree analysis then delivered the wider point: the two lineages expanded their tyrosinase sets on their own. Two unrelated animals arrived at DOPA glue by parallel evolution, a case of the same chemistry found twice.
Catalog record
| CREATOR | Emilie Duthoo, Jérôme Delroisse, Barbara Maldonado, Fabien Sinot, Cyril Mascolo, Ruddy Wattiez, Pascal Jean Lopez, Cécile Van de Weerdt, Matthew J. Harrington, Patrick Flammang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 81 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |