Oviductus Ranae Promotes Follicle Growth Through the PI3K/AKT Signaling Pathway In Vivo and In Vitro in Rat
Hongyu Zhao, Yu Wang, Xueyuan Sun, Xingyao He, Lin Di, Zhen Yang · 2024
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Description
Hongyu Zhao and co-authors test a traditional remedy, Oviductus Ranae, a frog-derived product used as both food and medicine with a reputation for estrogen-like effects. The team asked whether it works by helping ovarian follicles grow, the step that sets hormone cycles. They dosed rats with the product and also grew rat follicles in dishes treated with it.
Treated follicles grew wider, and the fluid around them held more estrogen. In the animals, blood estrogen and progesterone rose, ripe follicles grew more numerous, and fewer follicles withered. A known growth pathway in the ovary, PI3K and AKT, switched on more strongly, along with the receptor for a key fertility hormone, while a brake on that pathway eased off. The authors conclude the product promotes follicle growth through this pathway, which would explain its estrogen-like name.
Catalog record
| CREATOR | Hongyu Zhao, Yu Wang, Xueyuan Sun, Xingyao He, Lin Di, Zhen Yang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |