In silico neoantigen screening and HLA multimer-based validation identify immunogenic neopeptide in multifocal lung adenocarcinoma
Xin Wang, Lang Jiang, Juan Zhao, Mi Wu, Jin Xiong, Xiongwen Wu, Xiufang Weng · 2024
Read In silico neoantigen screening and HLA multimer-based validation identify immunogenic neopeptide in multifocal lung adenocarcinoma by Xin Wang, Lang Jiang, Juan Zhao, Mi Wu, Jin Xiong, Xiongwen Wu, Xiufang Weng (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11666526.txt.
Description
Xin Wang and co-authors screened for immune targets created by mutations in lung cancer, in a 2024 study. Mutated proteins can flag cancer cells for immune attack, which makes them prized targets for personal vaccines. The catch is variety: patients differ, and even spots within one patient's cancer differ. The team took seven tumor samples from four patients with a common lung cancer type, plus matched healthy tissue and blood.
Gene reads showed a shared mutation pattern, heavy in single-letter changes, across patients and across tumor spots. Three genes mutated in all four patients. Three short protein pieces, found in at least two spots of one patient, bound a key immune marker well. One piece drove immune killer cells to grow and release an attack signal far more than its normal twin. The authors offer their pipeline as a template for personal lung cancer vaccines.
Catalog record
| CREATOR | Xin Wang, Lang Jiang, Juan Zhao, Mi Wu, Jin Xiong, Xiongwen Wu, Xiufang Weng |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |