Case report: Low-dose interleukin-2: a treatment of bullous pemphigoid with predominantly perifollicular blistering caused by PD-1/PD-L1 inhibitor
Yingyue Zhang, Xianwei Cao, Jianbo Tong · 2024
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Description
Yingyue Zhang, Xianwei Cao and Jianbo Tong report low-dose interleukin-2 as a treatment for a blistering skin disease triggered by cancer immunotherapy. The disease, bullous pemphigoid, arose here from PD-1 and PD-L1 blocking drugs, with blisters clustered around hair follicles. Patients received a standardized low-dose interleukin-2 plan, and disease, itch and life quality scores were tracked, along with blood immune cells and signals.
After treatment, all three scores fell clearly. Counts of B cells, both main T cell types and regulatory T cells dropped from baseline, as did several cytokine levels. The authors conclude the low-dose plan is an effective option for this drug-caused skin disease.
Catalog record
| CREATOR | Yingyue Zhang, Xianwei Cao, Jianbo Tong |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 12 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |