Geranylgeranyl Pyrophosphate Promotes Profibrotic Factors and Collagen‐Specific Chaperone HSP47 in Fibroblasts
Gracious R. Ross, Sanja Vodanovic‐Jankovic, Ivor J. Benjamin · 2024
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Description
Gracious Ross, Sanja Vodanovic-Jankovic, and Ivor Benjamin study the part a lipid molecule plays in fibroblast activation in a 2024 paper. Fibrosis, excess matrix buildup, drives organ failure and much death worldwide. Fibroblasts turn into contractile myofibroblasts during fibrosis, gaining marker proteins including a collagen specific chaperone. The team posited that a molecule needed for protein prenylation, a lipid tagging process, is key to that switch.
Blocking the making of the molecule sharply cut the switch driven by a growth factor, and adding it back revived it. Blocking either of two tagging enzymes also lowered key markers. A surprise finding was a steep drop in the collagen chaperone, a sign of a narrow role downstream. Readers learn lipid tagging gates a core fibrosis program.
Catalog record
| CREATOR | Gracious R. Ross, Sanja Vodanovic‐Jankovic, Ivor J. Benjamin |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |