A bespoke water T–maze apparatus and protocol: an optimized, reliable, and repeatable method for screening learning, memory, and executive functioning in laboratory mice
Jeremy Davidson Bailoo, Susan E. Bergeson, Igor Ponomarev, Joshua O. Willms, Brent R. Kisby, Gail A. Cornwall, Clinton C. MacDonald, J. Josh Lawrence, Vadivel Ganapathy, Sathish Sivaprakasam, Praneetha Panthagani, Scott Trasti, Justin A. Varholick, Michael Findlater, Amrika Deonarine · 2024
Read A bespoke water T–maze apparatus and protocol: an optimized, reliable, and repeatable method for screening learning, memory, and executive functioning in laboratory mice by Jeremy Davidson Bailoo, Susan E. Bergeson, Igor Ponomarev, Joshua O. Willms, Brent R. Kisby, Gail A. Cornwall, Clinton C. MacDonald, J. Josh Lawrence, Vadivel Ganapathy, Sathish Sivaprakasam, Praneetha Panthagani, Scott Trasti, Justin A. Varholick, Michael Findlater, Amrika Deonarine (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11666379.txt.
Description
Jeremy Davidson Bailoo and co-authors describe in 2024 a water maze built to test learning and memory in lab mice with less stress than the standard maze. The standard test, a round pool, is the most used assay of its kind. Reviews have found that its methods vary a lot between labs, and that the swimming is stressful in each trial and across days.
Stress clouds attention and the fixing of memories, which can warp results. Behavior in the round pool is also hard to read, since mice hug the wall or float. The team's T shaped water maze and its protocol aim for steady, repeatable results with clearer behavior to score. A calmer, more standard test would help drug and brain studies compare results across labs. The paper sets out the design and the steps in full.
Catalog record
| CREATOR | Jeremy Davidson Bailoo, Susan E. Bergeson, Igor Ponomarev, Joshua O. Willms, Brent R. Kisby, Gail A. Cornwall, Clinton C. MacDonald, J. Josh Lawrence, Vadivel Ganapathy, Sathish Sivaprakasam, Praneetha Panthagani, Scott Trasti, Justin A. Varholick, Michael Findlater, Amrika Deonarine |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |