Genetic synchronization of the brain and liver molecular clocks defend against chrono-metabolic disease
Lauren N. Woodie, Ahren J. Alberto, Brianna M. Krusen, Lily C. Melink, Mitchell A. Lazar · 2024
Read Genetic synchronization of the brain and liver molecular clocks defend against chrono-metabolic disease by Lauren N. Woodie, Ahren J. Alberto, Brianna M. Krusen, Lily C. Melink, Mitchell A. Lazar (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11665897.txt.
Description
Lauren N Woodie and four co-authors show that when brain and liver clocks tick in sync, mice are guarded from metabolic disease. Their paper is from two thousand twenty-four. Most cells hold a daily clock, tuned by a master clock in the brain. When the two fall out of step, as in shift work, metabolism suffers.
They use mice whose master clock runs short, which makes them prone to weight gain on a rich diet. Liver cells with a matched short clock are then bred in. Those mice are spared the extra weight gain and liver fat, while their short daily rhythm stays. Sync inside the body, not with the world, may be the key target.
Catalog record
| CREATOR | Lauren N. Woodie, Ahren J. Alberto, Brianna M. Krusen, Lily C. Melink, Mitchell A. Lazar |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 21 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |