The ternary complex of Mn2+, synthetic decapeptide DP1 (DEHGTAVMLK), and orthophosphate is a superb antioxidant
Hao Yang, Ajay Sharma, Michael J. Daly, Brian M. Hoffman · 2024
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Description
Hao Yang, Ajay Sharma, Michael Daly, and Brian Hoffman published a 2024 study of a powerful antioxidant built from manganese, a short designer peptide, and phosphate. Such manganese mixtures protect the toughest known bacteria from radiation, and a lab-made blend based on them has revived work on radiation-killed vaccines. The team asked which exact form of the mixture does the protective work.
Careful binding tests gave a surprise. The peptide alone grips manganese only weakly, and phosphate grips it more strongly. Together, though, the three parts form a joint complex that binds better than phosphate alone. The authors identify that three-part complex as the active antioxidant. The finding helps chemists design protective blends on purpose rather than by trial and error.
Catalog record
| CREATOR | Hao Yang, Ajay Sharma, Michael J. Daly, Brian M. Hoffman |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |