Bakuchiol from Cullen corylifolium and its efficacy on apoptosis and autophagy in HepG2 cells
Yeong-Geun Lee, Seon-A Jang, Hae Seong Song, Jeong Eun Kwon, Minsung Ko, Woojae Hong, Ahyeong Gwon, Se-Eun Park, Yujin Jeong, Hyunggun Kim, Se Chan Kang · 2024
Read Bakuchiol from Cullen corylifolium and its efficacy on apoptosis and autophagy in HepG2 cells by Yeong-Geun Lee, Seon-A Jang, Hae Seong Song, Jeong Eun Kwon, Minsung Ko, Woojae Hong, Ahyeong Gwon, Se-Eun Park, Yujin Jeong, Hyunggun Kim, Se Chan Kang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11664279.txt.
Description
Yeong-Geun Lee and co-authors test a plant compound against liver cancer cells in a 2024 study. Bakuchiol comes from the seeds of Cullen corylifolium and is known for hormone-like and germ-fighting traits. Its power against liver cancer was untested. The team compared it with three cousin flavonoids from the same plant on HepG2 cells.
Bakuchiol stood out, driving the cancer cells into apoptosis, programmed death. Both death pathways, internal and external, switched on, judged by their protein ratios. The compound also froze the cell cycle early, lowering two driver proteins while raising three brakes. It woke an energy sensor and a cleanup pathway, and damped a growth signal. The authors conclude bakuchiol kills liver cancer cells by twin routes, death and self-digestion. They present it as a lead worth developing for this hard cancer.
Catalog record
| CREATOR | Yeong-Geun Lee, Seon-A Jang, Hae Seong Song, Jeong Eun Kwon, Minsung Ko, Woojae Hong, Ahyeong Gwon, Se-Eun Park, Yujin Jeong, Hyunggun Kim, Se Chan Kang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |