Adaptable Manufacturing and Biofabrication of Milliscale Organ Chips With Perfusable Vascular Beds
Charles Ethan Byrne, Ashley T Martier, Gideon Wills Kpeli, Kevin Michael Conrad, William Bralower, Elisabet Olsen, Gabrielle Fortes, Caroline C Culp, Max Wendell, Keefer A Boone, Matthew R Burow, Mark J Mondrinos · 2024
Read Adaptable Manufacturing and Biofabrication of Milliscale Organ Chips With Perfusable Vascular Beds by Charles Ethan Byrne, Ashley T Martier, Gideon Wills Kpeli, Kevin Michael Conrad, William Bralower, Elisabet Olsen, Gabrielle Fortes, Caroline C Culp, Max Wendell, Keefer A Boone, Matthew R Burow, Mark J Mondrinos (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11664230.txt.
Description
Charles Ethan Byrne and co-authors report, in 2024, manufacturing methods that make organ-on-chip devices easier to build and share. These chips grow tissues with working blood vessel beds, letting researchers model vessel physiology in a dish. Cheap desktop printers can mold the chips, but print flaws distort shapes and cloud the material.
The team gives post-processing steps that yield cured, flat, clear chips that bond reliably. Loading tests picked a chip design that target users could fill reproducibly. With that design, they grew vessel networks inside tissue and lined the borders with vessel cells so the networks connected. Flow methods were compared for conditioning the beds.
Catalog record
| CREATOR | Charles Ethan Byrne, Ashley T Martier, Gideon Wills Kpeli, Kevin Michael Conrad, William Bralower, Elisabet Olsen, Gabrielle Fortes, Caroline C Culp, Max Wendell, Keefer A Boone, Matthew R Burow, Mark J Mondrinos |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |