Catalyzing Pharmacogenomic Analysis for Informing Pain Treatment (C-PAIN): A Randomized Trial of Preemptive CYP2D6 Genotyping in Cancer Palliative Care
Youngwoo Cho, Theodore Karrison, Matthew M Jack, Anish R Choksi, Randall W Knoebel, Kiang-Teck J Yeo, Samuel L Volchenboum, Russell Z Szmulewitz, Everett E Vokes, Mark J Ratain, Peter H O’Donnell · 2024
Read Catalyzing Pharmacogenomic Analysis for Informing Pain Treatment (C-PAIN): A Randomized Trial of Preemptive CYP2D6 Genotyping in Cancer Palliative Care by Youngwoo Cho, Theodore Karrison, Matthew M Jack, Anish R Choksi, Randall W Knoebel, Kiang-Teck J Yeo, Samuel L Volchenboum, Russell Z Szmulewitz, Everett E Vokes, Mark J Ratain, Peter H O’Donnell (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11664000.txt.
Description
Youngwoo Cho and ten co-authors wrote this 2024 protocol for a trial testing whether a gene test can ease cancer pain. Some common opioids only work after the body converts them, and a gene called CYP2D6 controls that conversion. Slow or fast converters get too little relief or too much drug. The trial enrolls patients with spreading solid tumors who are about to start such opioids.
Half will be gene-tested up front, with results fed to prescribers through the medical record as dosing guidance. The other half get usual care. The main yardstick is a combined pain score over the first forty-five days after the first prescription. The team will also track side effects, hospital visits, and total opioid dose. The design tests whether preemptive gene knowledge beats the current trial-and-error in palliative care.
Catalog record
| CREATOR | Youngwoo Cho, Theodore Karrison, Matthew M Jack, Anish R Choksi, Randall W Knoebel, Kiang-Teck J Yeo, Samuel L Volchenboum, Russell Z Szmulewitz, Everett E Vokes, Mark J Ratain, Peter H O’Donnell |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |