Multiple activities of sphingomyelin synthase 2 generate saturated fatty acid– and/or monounsaturated fatty acid–containing diacylglycerol
Chiaki Murakami, Kamila Dilimulati, Kyoko Atsuta-Tsunoda, Takuma Kawai, Sho Inomata, Yasuhisa Hijikata, Hiromichi Sakai, Fumio Sakane · 2024
Read Multiple activities of sphingomyelin synthase 2 generate saturated fatty acid– and/or monounsaturated fatty acid–containing diacylglycerol by Chiaki Murakami, Kamila Dilimulati, Kyoko Atsuta-Tsunoda, Takuma Kawai, Sho Inomata, Yasuhisa Hijikata, Hiromichi Sakai, Fumio Sakane (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11663969.txt.
Description
Chiaki Murakami and co-authors show that one human enzyme long known for making a membrane fat can also do three other jobs, in a study from 2024. Two of those jobs make a signal fat from membrane parts, and their source genes had stayed unknown for decades.
In test tubes and in rebuilt membrane bubbles, the enzyme split two kinds of membrane fat and built a third kind. It favored membrane fats with plain or single bend tails. A known blocker stopped all four jobs, as did zinc ions. The signal fat itself slowed the main job, a built in brake.
Catalog record
| CREATOR | Chiaki Murakami, Kamila Dilimulati, Kyoko Atsuta-Tsunoda, Takuma Kawai, Sho Inomata, Yasuhisa Hijikata, Hiromichi Sakai, Fumio Sakane |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 112 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |