MS4A superfamily molecules in tumors, Alzheimer’s and autoimmune diseases
Xuejiao Luo, Bin Luo, Lei Fei, Qinggao Zhang, Xinyu Liang, Yongwen Chen, Xueqin Zhou · 2024
Read MS4A superfamily molecules in tumors, Alzheimer’s and autoimmune diseases by Xuejiao Luo, Bin Luo, Lei Fei, Qinggao Zhang, Xinyu Liang, Yongwen Chen, Xueqin Zhou (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11663944.txt.
Description
Xuejiao Luo and co-authors review a family of immune surface proteins tied to several major diseases. Their 2024 paper covers the MS4A superfamily, four-pass membrane proteins found mostly on immune cells. Eighteen members are known in humans and twenty-three in mice, each with its own cell home.
Early work cast most of them as calcium channels. Newer studies show some also act as partners, joining sensing and antibody receptors to pass signals inward and steer cell growth. Animal and human genetic evidence links the family to cancer, infection, allergy, brain degeneration, and autoimmune disease. The authors collect the recent progress and spell out how each member works, aiming to mark which ones could serve as drug targets.
Catalog record
| CREATOR | Xuejiao Luo, Bin Luo, Lei Fei, Qinggao Zhang, Xinyu Liang, Yongwen Chen, Xueqin Zhou |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |