Emerging influence of RNA post-transcriptional modifications in the synovial homeostasis of rheumatoid arthritis
Madiha Fatima, Fengmei Huang, Xiaohong Fu · 2024
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Description
Madiha Fatima, Fengmei Huang, and Xiaohong Fu review how chemical edits to RNA shape the joint lining in rheumatoid arthritis. Their 2024 paper describes the synovium, the tissue that cushions and feeds the joint, as the disease's main battleground. In arthritis it thickens, fills with immune cells, and drives the remodeling that destroys joint function.
The review gathers recent work on RNA modifications, marks added after the RNA is written that steer its stability and movement within the cell. Faulty marking, above all faulty methylation, feeds the disease process. The marks link the joint's resident macrophages, fibroblasts, and immune cells into one network, part of a feedback loop among bone, cartilage, and synovium. The authors argue these modifications are a promising drug target: correcting them could restore balance in the joint lining rather than only damping inflammation downstream.
Catalog record
| CREATOR | Madiha Fatima, Fengmei Huang, Xiaohong Fu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |