TIGIT and PD-L1 co-blockade promotes clonal expansion of multipotent, non-exhausted antitumor T cells by facilitating co-stimulation
Katherine Nutsch, Karl L. Banta, Thomas D. Wu, Charles W. Tran, Stephanie Mittman, Ellen Duong, Barzin Y. Nabet, Yan Qu, Katherine Williams, Sören Müller, Namrata S. Patil, Eugene Y. Chiang, Ira Mellman · 2024
Read TIGIT and PD-L1 co-blockade promotes clonal expansion of multipotent, non-exhausted antitumor T cells by facilitating co-stimulation by Katherine Nutsch, Karl L. Banta, Thomas D. Wu, Charles W. Tran, Stephanie Mittman, Ellen Duong, Barzin Y. Nabet, Yan Qu, Katherine Williams, Sören Müller, Namrata S. Patil, Eugene Y. Chiang, Ira Mellman (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11663793.txt.
Description
Twelve authors, led by Katherine Nutsch, show why blocking two immune brakes beats one in this 2024 cancer paper. Drugs that release the PD-1 brake help T cells attack tumors, and adding a second brake release, TIGIT, showed promise in mice and patients. What the pair actually does to T cells was unclear.
In mouse tumors, the double blockade sparked growth of tumor-targeting T cell clones. The push came through a co-stimulatory receptor, CD226, that the brakes normally restrain. The new clones rose from stem-like cells in nearby lymph nodes, traveled through the blood as a distinct population, then multiplied in the tumor and matured into killers. Crucially, these cells were multipotent and not worn out. The work explains the combo's power and points at markers for patients most likely to benefit.
Catalog record
| CREATOR | Katherine Nutsch, Karl L. Banta, Thomas D. Wu, Charles W. Tran, Stephanie Mittman, Ellen Duong, Barzin Y. Nabet, Yan Qu, Katherine Williams, Sören Müller, Namrata S. Patil, Eugene Y. Chiang, Ira Mellman |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 93 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |