Generation of a SARS-CoV-2-susceptible mouse model using adenovirus vector expressing human angiotensin-converting enzyme 2 driven by an elongation factor 1α promoter with leftward orientation
Yusuke Matsumoto, Tomoko Honda, Fumihiko Yasui, Akinori Endo, Takahiro Sanada, Sakiko Toyama, Asako Takagi, Tsubasa Munakata, Risa Kono, Kenzaburo Yamaji, Naoki Yamamoto, Yasushi Saeki, Michinori Kohara · 2024
Read Generation of a SARS-CoV-2-susceptible mouse model using adenovirus vector expressing human angiotensin-converting enzyme 2 driven by an elongation factor 1α promoter with leftward orientation by Yusuke Matsumoto, Tomoko Honda, Fumihiko Yasui, Akinori Endo, Takahiro Sanada, Sakiko Toyama, Asako Takagi, Tsubasa Munakata, Risa Kono, Kenzaburo Yamaji, Naoki Yamamoto, Yasushi Saeki, Michinori Kohara (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11663739.txt.
Description
Yusuke Matsumoto and co-authors give ordinary mice COVID susceptibility by delivering the human virus receptor to their airways. Their 2024 study uses an adenovirus vector carrying the human ACE2 gene under a strong promoter set in reverse orientation. Such a model is needed to study how the virus damages lungs.
Infected mice develop severe pneumonia much like human cases, with heavy immune cell influx and strong viral growth. An early pandemic strain causes the worst weight loss. Alpha, Beta, and Gamma variants match it on tissue damage, viral load, and cytokine patterns. Protein profiling sets the early strain apart: complement activation and clotting run hotter. The authors argue that quirk may explain early strain severity and pandemic origins.
Catalog record
| CREATOR | Yusuke Matsumoto, Tomoko Honda, Fumihiko Yasui, Akinori Endo, Takahiro Sanada, Sakiko Toyama, Asako Takagi, Tsubasa Munakata, Risa Kono, Kenzaburo Yamaji, Naoki Yamamoto, Yasushi Saeki, Michinori Kohara |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |