Booster COVID-19 mRNA vaccination ameliorates impaired B-cell but not T-cell responses in older adults
Kohei Kometani, Takaaki Yorimitsu, Norihide Jo, Erina Yamaguchi, Osamu Kikuchi, Masaru Fukahori, Takeshi Sawada, Yoshitaka Tsujimoto, Ayana Sunami, Mengqian Li, Takeshi Ito, Yann Pretemer, Yuxian Gao, Yu Hidaka, Masaki Yamamoto, Natsuko Kaku, Yu Nakagama, Yasutoshi Kido, Alba Grifoni, Alessandro Set · 2024
Read Booster COVID-19 mRNA vaccination ameliorates impaired B-cell but not T-cell responses in older adults by Kohei Kometani, Takaaki Yorimitsu, Norihide Jo, Erina Yamaguchi, Osamu Kikuchi, Masaru Fukahori, Takeshi Sawada, Yoshitaka Tsujimoto, Ayana Sunami, Mengqian Li, Takeshi Ito, Yann Pretemer, Yuxian Gao, Yu Hidaka, Masaki Yamamoto, Natsuko Kaku, Yu Nakagama, Yasutoshi Kido, Alba Grifoni, Alessandro Set (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11663736.txt.
Description
The authors compare how COVID booster shots refresh immune memory in older versus younger adults. Older adults made more antibody after a booster, yet their helper and killer T cell responses stayed weaker. B cell responses told a different story.
Before boosting, older adults lagged in B cells too. After the booster, their B cell response rose to match the younger group. T cell measures, though, barely budged. The team concludes boosters fix the antibody arm in old age but leave the T cell arm short, a split that should shape vaccine design for the elderly.
Catalog record
| CREATOR | Kohei Kometani, Takaaki Yorimitsu, Norihide Jo, Erina Yamaguchi, Osamu Kikuchi, Masaru Fukahori, Takeshi Sawada, Yoshitaka Tsujimoto, Ayana Sunami, Mengqian Li, Takeshi Ito, Yann Pretemer, Yuxian Gao, Yu Hidaka, Masaki Yamamoto, Natsuko Kaku, Yu Nakagama, Yasutoshi Kido, Alba Grifoni, Alessandro Set |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |