CAF-1 promotes efficient PrimPol recruitment to nascent DNA for single-stranded DNA gap formation
Joshua Straka, Jude B Khatib, Lindsey Pale, Claudia M Nicolae, George-Lucian Moldovan · 2024
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Description
Joshua Straka and co-authors uncover a fresh role for a histone helper in how cells patch stalled DNA copying, in this 2024 study. Single-strand gaps left at forks can turn into deadly breaks. Tumors that lack a repair path die from such gaps under drug attack.
The helper, CAF-1, was known for guarding stalled forks. The new work shows it also feeds gap growth, in both normal and repair-lacking cells. The trick is not its packaging job but its seat at the fork, where it guides in the restart enzyme PrimPol. Cells that lose the helper resist drugs by making fewer gaps. The finding reframes a known drug-response clue.
Catalog record
| CREATOR | Joshua Straka, Jude B Khatib, Lindsey Pale, Claudia M Nicolae, George-Lucian Moldovan |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |