Bacterial WYL domain transcriptional repressors sense single-stranded DNA to control gene expression
Chelsea L Blankenchip, Kevin D Corbett · 2024
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Description
Chelsea Blankenchip and Kevin Corbett show how a bacterial repressor senses loose DNA strands to switch on immune defenses, in a study from 2024. Bacteria carry immune systems against the viruses that hunt them. Those systems must stay off until truly needed, or they harm their host. The repressor, CapW, holds one such system quiet by gripping double-stranded DNA.
When damage frees single strands, CapW grabs them with a special domain. That grab changes its shape and frees the genes it guards. In a test bacterium, this switch proved key to fighting off a dormant virus. The authors map the full chain from sensing to gene release. Their work explains a whole family of like repressors. It also shows how bacteria balance defense against self-harm.
Catalog record
| CREATOR | Chelsea L Blankenchip, Kevin D Corbett |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |